Outcome Measures

The following outcome measures are available at Hadassah Brainlabs:


Behavioral Analysis

Motor domain

Motor Scores
Grip test; Catalepsy test; Open field; Cylinder test; Rotarod

Clinical Scores
EAE; ALS; Prion; NSS

Parkinson’s Disease Scores
Non-Pharmacological: Stepping, Placing, Wire grasping test, Pole test
Pharmacological: Rotational asymmetry


Cognitive, learning and memory domain
Novel object recognition; Morris water maze: Attentional set shifting; Radial arm water maze; Cued and context fear conditioning; T-maze; Y-maze


Psychosis-like domain
MK801 – induced hyperlocomotion; MK-801-induced pre-pulse inhibition


Depressive-like domain
Forced swim test; Novelty suppressed feeding; Saccharin preference; Tail suspension


Anxiety-like domain
Elevated plus maze; Open field; Light-dark box; Stress induced hyperthermia; Startle response; Peripheral stress-related biomarkers (corticosterone, ACTH)


Social domain
Three chambers sociability and social novelty test; Social interaction in pairs; Resident intruder test


Neuropathology

Cells in the CNS
Neurons, Astrocytes, Microglia, Oligodendrocytes; Blood vessels; Transplanted cells; Neurogenesis

Neuroinflammation
T-cells, B-cells, Microglia/Macrophages, Perivascular/ Meningeal Infiltrates

Neurodegeneration
Neurofibrillary tangles, Amyloid plaques; De/Myelination; Axonal damage; Prions; Apoptosis


Biochemical Analysis

Proteins (Soluble, resistant, phosphorylated, glycosylated)

Growth factors, AD biomarkers

Secretases activity


Immunological Assays

T-cell proliferation, Ab titers

Cytokines

Typing of immune cells


Genetic and Molecular Biology Assays

Genotyping

Gene expression


Electrophysiology

Video-EEG monitoring


Brain Imaging

MRI

PET