MRI

The small animal MRI system is an indispensable tool for in vivo structural and functional research. MRI can be used for a variety of purposes either to get direct information on brain physiology or to test clinical hypotheses, diagnostic methods, effect of drugs etc.  The method’s non-invasiveness enables a direct translation to humans with high predictive validity. Animal MRI research can be divided into anatomical and functional. Anatomy uses include monitoring of structural (grey and white matter) volume changes and of regional MRI parameter changes (e.g., diffusion). Functional uses include monitoring changes in blood flows and volume, changes in brain activity and brain connectivity, at both global and local levels, tracking of innovative treatment modalities (such as stem cell therapy) and monitoring changes in the white matter (using for example DTI  technique. A Bruker 7T BioSpin system of the MRI lab will be available for the project. The system is currently being upgraded (from 4.7T to 7T), including magnet replacement and the purchase of several radio-frequency coils. The MRI system is SPF approved, thus enabling bidirectional rodent exchange with other SPF approved facilities.

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