Prof. Hanna Rosenmann Ph.D.

Hanna Rosenmann 2Appointment: Associate Professor of Experimental Neurology; Director, Laboratory of Neurology, Department of Neurology

Area of expertise: : Tauopathies, Alzheimer’s diseases, Molecular Neurogenetics.

Tel: 02-6776954; Email: rosenman@hadassah.org.il

 

Selected Research Publications

Lossos A, Reches A, Gal A, Newman JP, Soffer D, Gomori JM, Boher M, Ekstein D, Biran I, Meiner Z, Abramsky O, Rosenmann H (2003) Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family. J Neurol 250(6):733-740

Rosenmann H, Ginzburg I (2003) Regulation of localization and phosphorylation of tau. 8th Alzheimer’s disease Book of Proceedings, 287-301

Rosenmann H, Meiner Z, Kahana E, Aladjem Z, Friedman G, Ben-Yehuda A, Grenader T. Wertman E, Abramsky O (2004) An association study of a polymorphism in the heparane sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer’s disease. Am J Med Genet (Neuropsychi Genet) 128B(1):123-125

Rosenmann H, Meiner Z, Dresner-Pollak R, Kahana E, Aladjem Z, Grenader T, Wertman E, Abramsky O (2004) Lack of association of interleukin-1beta polymorphism with Alzheimer’s disease in the Jewish population. Neurosci Lett 363(2):131-133

Meiner Z, Newman J, Rosenman H, Soffer D, Steiner I (2005) Frontotemporal dementia with ubiquitinated neuronal inclusions and visuospatial impairment. Neurology 65(3):478-480

Rosenmann H, Meiner Z, Geylis V, Steinitz M (2006) Naturally occuring antibodies against unphosphorylated and phosphorylated tau protein in sera of AD and healthy subjects. Neurosc Lett 410:90-93

Rosenmann H, Grigoriadis H, Karussis D, Mizrachi-Koll R, Boimel M, Touloumi O, Ovadia H, Abramsky O (2006) Experimental Autoimmune Tauopathy: immunoreactivity against tau-microtubule-associated protein induces a neurological disease in mice. Arch Neurol 63:1459-1467

Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E (2008) A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics. Exp Neurol 212(1):71-84

Boimel M, Grigoriadis N, Lourbopoulos A, Rozenstein L, Touloumi O, Abramsky O, Rosenmann H (2009) Statins reduce neurofibrillary-tangle burden in a transgenic mouse model for tauopathy and Alzheimer’s-disease. J Neuropathol Exp Neurol 68:314-325

Shiryaev N, Jouroukhin Y, Giladi E, Polyzoidou E, Grigoriadis NC, Rosenmann H, Gozes I (2009) NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model. Neurobiol Dis 34(2):381-388

Boimel M, Grigoriadis N, Lourbopoulos A, Haber E, Abramsky O, Rosenmann H (2010) Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Exp Neurol 224(2):472-485

Meiner Z, Kahana E, Baitcher F, Korczyn AD, Chapman J, Cohen OS, Milo R, Aharon-Perez J, Abramsky O, Gabizon R (2010) Tau and 14-3-3 of genetic and sporadic Creutzfeldt Jakob disease patients in Israel. J Neurol 258(2):255-262

Inbar D, Belinson H, Rosenmann H, Michaelson DM (2010) The possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade. Neurodegener Dis. 7:16-23

Boimel M, Grigoriadis N, Lourbopoulos A, Haber E, Abramsky O, Rosenmann H (2010) Efficacy and safety of immunization with phosphorylated-tau against neurofibrillary-tangles in mice. Exp Neurol 224: 472-485

Rosenmann H (2011) Cerebrospinal fluid biomarkers for amyloid and tau pathology in Alzheimer’s disease J Mol Neurosci 47(1):1-14

Lahiani-Cohen I, Lourbopoulos A, Haber E, Rozenstein-Tsalkovich L, Abramsky O, Grigoriadis N, Rosenmann H (2011) Moderate environmental enrichment mitigates tauopathy in a neurofibrillary tangle mouse model. J Neuropathol Exp Neurol 70(7):610-621

Rosenmann H (2011) CSF biomarkers for amyloid and tau pathology in Alzheimer’s disease. J Mol Neurosci 47(1):1-14

Gotkine M, Rozenstein L, Einstein O, Abramsky O, Argov Z, Rosenmann H (2013) Presymptomatic Treatment with Acetylcholinesterase Antisense Oligonucleotides Prolongs Survival in ALS (G93A-SOD1) Mice. BioMed research international 2013

Rosenmann H (2013) Immunotherapy for Targeting Tau Pathology in Alzheimer’s Disease and Tauopathies. Current Alzheimer Research 10(3):217-228

Rozenstein-Tsalkovich L, Grigoriadis N, Lourbopoulos A, Nousiopoulou E, Kassis I, Abramsky O, Karussis D, Rosenmann H (2013) Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation. Exp Neurol 248:451-456