Mice are infected with mouse prions either i.c. or i.p and followed for disease signs that first appear at about 10 and 150 days, respectably.  Mice usually are sacrificed 10-165 days after the appearance of clinical signs. Biochemical and pathological examination reveal accumulation of PrPSc  in brains and spleens, gliosis and neuronal death.

References

Haviv Y, Avrahami D, Ovadia H, Ben-Hur T, Gabizon R, Sharon R (2008) Induced neuroprotection independently from prpsc accumulation in a mouse model for prion disease treated with simvastatin. Arch Neurol 65(6):762-75.

Avrahami D, Gabizon R (2010) Age-related alterations affect the susceptibility of mice to prion infection. Neurobiol Aging 32(11):2006-2015