Amyloid (APPswe,PSEN1De9) tg-mice present amyloid plaques by 9 months of age and develop cognitive deficits at 13 months.

Improved performance in T-maze and reduced amyloid plaque burden in APPswe,PSEN1De9 tg mice treated with experimental therapy

References

Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR (2001) Co-expression of multiple transgenes in mouse CNS: A comparison of strategies. Biomol Eng 17(6):157-165

Benhamron S, Rozenstein-Tsalkovich L, Nitzan K, Abramsky O, Rosenmann H (2018) . Phos-tau peptide immunization of amyloid-tg-mice reduced non-mutant phos-tau pathology, improved cognition and reduced amyloid plaques. Exp Neurol. 303:48-58.