Intracerebral hemorrhage is induced in mice by stereotaxic injection of collagenase IV into the caudate nucleus  or into the frontal cortex. The amount of collagenase injected correlates with hemorrhage size, histological damage and clinical presentation.

References

Omary R, Chernoguz D, Lasri V, Leker RR (2012) Decompressive hemicraniectomy reduces mortality in an animal model of intracerebral hemorrhage. J Mol Neurosci 49(1):157-161