Prof. Dimitrios Karussis M.D., Ph.D.

Dimitrios KarussisAppointment: Professor of Neurology; Head, Multiple Sclerosis Center, Department of Neurology

Area of expertise: Mesenchymal stem cells, neuroimmunology.

Tel: 02-6776939; Email: dimitriosk@ekmd.huji.ac.il.

 

Selected Research Publications

Karussis D, Lehmann D, Slavin S, Vourka-Karussis U, Mizrachi-Koll R, Ovadia H, Kalland T, Abramsky O (1993) Successful treatment of chronic relapsing experimental autoimmune encephalomyelitis by the synthetic immunomodulator quinoline-3-carboxamide (linomide.( Proc Nat Acad Sci 90:6400-6404

Karussis D, Vourka-Karussis U, Lehmann D, Ovadia H, Mizrachi-Koll R, Slavin S, Abramsky, O (1993) Inhibition of experimental autoimmune encephalomyelitis with linomide (LS-2616), a synthetic immunomodulator . Ann Neurol 34(5):654-660

Karussis D, Vourka-Karussis U, Ovadia H, Lehmann D, Mizrachi-Koll R, Ben-Nun A, Abramsky O, Slavin S (1993) Prevention and reversal of adoptively transfered chronic-relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation . J Clin Invest 92(2):765-772

Karussis D, Meiner Z, Lehmann D, Gomori M, Schwarz A, Linde A, Gjorstrup P, Abramsky O (1996) Treatment of secondary progressive multiple sclerosis with the immunomodulator Linomide: A pilot double blind placebo controlled study with monthly MRI evaluation. Neurology 47(2):341-346

Karussis D, Ashkenazi R, Leker O, Abramsky (1998) A subgroup of MS patients and anticardiolipin Abs and unusual clinical manifestations; Do they represent a new nosological entity ? Ann Neurol 44(4):629-634

Ben-Hur T, Einstein O, Mizrachi-Koll R , Ben-Menachem O, Reinhartz E, Karussis D , Abramsky O (2003) Transplanted multipotential neural precursor cells migrate into inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia 41(1): 73-80

Karussis D, Biermann LD, Bohlega S, Boiko A , Chofflon M, Fazekas F, Freedman M, Gebeily S, Gouider R, Havrdova E , Jakab G, Karabudak R, Miller A, the International Working Group for Treatment Optimization in MS (2006) A recommended treatment algorithm in relapsing multiple sclerosis: report of an international consensus meeting. Eur J Neurol 13(1):61-71

Karussis D, Kassis I, Gowda-Kurkalli B, Slavin S (2008) Immunomodulation and neuroptotection with mesenchymal bone marrow stem cells (MSCs): A proposed treatment for multiple sclerosis and other neuroimunological/neurodegenerative diseases. J Neurol Sci 265(1-2):131-135

Kassis I, Grigoriadis N, Gowda-Kurkalli B, Ben-Hur T, Einstein O, Mizrachi-Koll R, Slavin S, Abramsky O, Karussis D (2008) Immunomodulation and neuroprotection with bone marrow derived MSCs in the chronic model of EAE . Archives of Neurology 65(6):753-761

Karussis D, Teitelbaum D, Sicsic C, Brenner T, the AC001 multi-center Israeli study group (2010) Long term treatment of multiple sclerosis with glatiramer acetate: Natural history of the subtypes of anti-glatiramer acetate antibodies and their correlation with clinical efficacy. J Neuroimmunol 30;220(1-2):125-130

Karussis D, Karageorgiou C, Gowda-Kurkalli B , Vaknin-Dembinsky A, Gomori JM, Kassis I, Bulte J, Ben-Hur T, Slavin S (2010) Safety and efficacy of autologous bone marrow derived mesenchymal stromal stem cells in patients with multiple sclerosis and amyotrophic lateral sclerosis Archives of Neurology 67(10): 1187-1119

Vaknin-Dembinsky A, Brill L, Kassis I, Petrou P , Ovadia H, Ben-Hur T, Abramsky O, Karussis D (2011) Myasthenia gravis with anti-aquaporin 4 antibodies and CNS involvement; a series of 14 patients. A new nosological entity or an overlap autoimmune syndrome. Archives of Neurology 68(12):1557-1561

Vaknin-Dembinsky A, Brill L, Kassis I, Petrou P , Ovadia H, Ben-Hur T, Abramsky O, Karussis D (2012) T-cell responses to aquaporin-4 in neuromyelitis optica (NMO). Neurology 28;79(9):945-946

Karussis D, Petrou P (2013) Acute disseminating encephalomyelitis (ADEM): post vaccination, post infectious and idiopathic. J Autoimmunity (in press)

Karussis D (2013) Update of the diagnostic criteria of Multiple sclerosis and various CNS demyelinating syndromes . J Autoimmunity (in press)

Karussis D, Petrou, P (2013) The spectrum of post-vaccination demyelinating CNS syndromes. Autoimmunity Reviews (in press)

Karussis D (2013) Immunotherapy of Multiple sclerosis; The state of the art. Biodrugs. 27(2):113-148

Karussis D, Petrou P, Vourka-Karussis U, Kassis I (2013) Hematopoietic stem cell transplantation in Multiple sclerosis.. Expert Reviews in Neurotherapeutics 13(5):567-578

Lilo E, Wald-Altman S, Solmesky LJ, Ben Yaakov K, Gershoni-Emek N, Bulvik S, Kassis I, Karussis D, Perlson E, Weil M (2013) Characterization of human sporadic ALS biomarkers in the familial ALS transgenic mSOD1(G93A) mouse model. Hum Mol Genet 22(23):4720-4725

Rozenstein-Tsalkovich L, Grigoriadis N, Lourbopoulos A, Nousiopoulou E, Kassis I, Abramsky O, Karussis D, Rosenmann H (2013) Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation. Exp Neurol 248:451-456

Kassis I, (CoPI), Petrou P, Vaknin-Dembinsky A, Hal M, Karussis D (2013) Mesenchymal Stem Cells (MSC) derived from mice with Experimental Autoimmune Encephalomyelitis (EAE) suppress EAE and have similar biological properties with MSC from healthy donors. Immunology Letters (in press)

Petrou P, Argov Z, Lennon VA, Gotkine M, Kassis I, Vaknin-Dembinsky A, Ben-Hur T, Offen D, Abramsky O, Melamed E, Karussis D (2013) Rare combination of myasthenia and ALS, responsive to MSC-NTF stem cell therapy. Muscle and Nerve, (in press)