Prof. Eyal Mishani Ph.D.

MishaniAppointment: Professor of Nuclear Medicine; Director, Cyclotron Radiochemistry Facility, Human Biology Research Center, Department of Nuclear Medicine

Area of expertise: Radiochemistry, PET imaging

Tel: 02 6777931; Email:


Selected Research Publications

Bocher M, Chisin R, Parag Y, Freedman N, Meir Weil Y, Lester H, Mishani E, Bonne O (2001) Cerebral activation associated with sexual arousal in response to a pornographic clip: A 15O-H2O PET study in heterosexual men. Neuroimage 14(1 Pt 1):105-117

Even-Sapir E, Metser U, Flusser G, Zuriel L, Kollender Y, Lerman H, Lievshitz G, Ron I, Mishani E (2004) Assessment of malignant skeletal disease: initial experience with 18F-fluoride PET/CT and comparison between 18F-fluoride PET and 18F-fluoride PET/CT. J Nucl Med 45(2):272-278

Mishani E, Abourbeh G, Rozen Y, Jacobson O, Laky D, Ben David I, Levitzki A, Shaul M (2004) Novel carbon-11 labeled 4-dimethylamino-but-2-enoic acid [4-(phenylamino)-quinazoline-6-yl]-amides: potential PET bioprobes for molecular imaging of EGFR-positive tumors. Nucl Med Biol 31(4):469-476

Mishani E, Abourbeh G, Jacobson O, Dissoki S, Ben Daniel R, Rozen Y, Shaul M, Levitzki A (2005) High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors. J Med Chem 48(16):5337-5348

Freedman NM, Mishani E, Krausz Y, Weininger J, Lester H, Blaugrund E, Ehrlich D, Chisin R (2005) In vivo measurement of brain monoamine oxidase B occupancy by rasagiline, using (11)C-l-deprenyl and PET. J Nucl Med 46(10):1618-1624

Mishani E, Abourbeh G (2007) Cancer molecular imaging: radionuclide-based biomarkers of the epidermal growth factor receptor (EGFR). Curr Top Med Chem 7(18):1755-1772

Abourbeh G, Dissoki S, Jacobson O, Litchi A, Ben Daniel R, Laki D, Levitzki A, Mishani E (2007) Evaluation of radiolabeled ML04, a putative irreversible inhibitor of epidermal growth factor receptor, as a bioprobe for PET imaging of EGFR-overexpressing tumors. Nucl Med Biol 34(1):55-70

Mishani E, Abourbeh G, Eiblmaier M, Anderson CJ (2008) Imaging of EGFR and EGFR tyrosine kinase overexpression in tumors by nuclear medicine modalities. Curr Pharm Des 14(28):2983-2998

Ilovich O, Jacobson O, Aviv Y, Litchi A, Chisin R, Mishani E (2008) Formation of fluorine-18 labeled diaryl ureas–labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis. Bioorg Med Chem 16(8):4242-4251

Ben-Daniel R, Deuther-Conrad W, Scheunemann M, Steinbach J, Brust P, Mishani E (2008) Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter. Bioorg Med Chem 16(12):6364-6370

Ilovich O, Billauer H, Dotan S, Mishani E (2009) Labeled 3-aryl-4-indolylmaleimide derivatives and their potential as angiogenic PET biomarkers. Bioorg Med Chem 18(2):612-620

Ilovich O, Billauer H, Dotan S, Freedman NM, Bocher M, Mishani E (2010) Novel and simple carbon-11-labeled ammonium salts as PET agents for myocardial perfusion imaging. Mol Imaging Biol 13(1):128-139

Ilovich O, Abourbeh G, Bocher M, Freedman N, Billauer H, Dotan S, Danenberg HD, Mishani E (2012) Structure–activity relationship and preclinical evaluation of carbon-11-labeled ammonium salts as PET–myocardial perfusion imaging agents. Mol Imaging Biol 14(5):625-636

Kepe V, Moghbel MC, Langstrom B, Zaidi H, Vinters HV, Huang SC, Satyamurthy N, Doudet D, Mishani E, Cohen RM, Hoilund-Carlsen PF, Alavi A, Barrio JR (2013) Amyloid-beta positron emission tomography imaging probes: a critical review. J Alzheimers Dis 36(4):613-631

Jacobson O, Abourbeh G, Tsvirkun D, Mishani E (2013) Rat imaging and in vivo stability studies using [11C]-dimethyl-diphenyl ammonium, a candidate agent for PET-myocardial perfusion imaging. Nucl Med Biol 40(8):967-973