Prof. Talma Brenner Ph.D.

Talma BrennerAppointment: Professor of Neurobiology, Laboratory of Experimental Neurology, Department of Neurology

Area of expertise: Myasthenia gravis, neuroinflammation.

Tel: 02-6776957; Email:


Selected Research Publications

Boneva N, Hamra-Amitay Y, Wirguin I, Brenner T (2006) Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis. Neurosci Res 55(1):40-44

Nizri E, Irony-Tur-Sinai M, Lavon I, Meshulam H, Amitai G, Brenner T (2007) IBU-octyl-cytisine, a novel bifunctional compound eliciting anti-inflammatory and cholinergic activity, ameliorates CNS inflammation by inhibition of T-cell activity. Int Immunopharmacol 7(9):1129-1139

Fuchs S, Feferman T, Meidler R, Margalit R, Sicsic C, Brenner T, Laub O, Souroujon MC (2008) Immunosuppression of EAMG by IVIG is mediated by a disease-specific anti-immunoglobulin fraction. Ann N Y Acad Sci 1132:244-248

Fuchs S. Fefferman T. Meidler R. Brenner T. Laub O (2008) Souroujon MC. The disease-specific arm of the therapeutic effect of intravenous immunoglobulin in autoimmune disease: experimental autoimmune myasthenia gravis as a model. Isr Med Assoc J 10:58-60

Fuchs S. Fefferman T. Meidler R. Margalit R. Sicsic C. Wang N. Zhu KY. Brenner T. Laub O. Souroujon MC (2008) A disease-specific fraction isolated from IVIG is essential for the immunosuppressive effect of IVIG in experimental autoimmune myasthenia gravis. J Neuroimmunology 194: 89-96

Nizri E, Irony-Tur-Sinai M, Faranesh N, Lavon I, Lavi E, Weinstock M, Brenner T (2008) Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine. J Neuroimmunol 203(1):12-22

Brenner T, Nizri E, Irony-Tur-Sinai M, Hamra-Amitay Y, Wirguin I (2008) Acetylcholinesterase inhibitors and cholinergic modulation in Myasthenia Gravis and neuroinflammation. J Neuroimmunol 201-202:121-127

Irony-Tur-Sinai M, Grigoriadis N, Tsiantoulas D, Touloumi O, Abramsky O, Brenner T (2009) Immunomodulation of EAE by alpha-fetoprotein involves elevation of immune cell apoptosis markers and the transcription factor FoxP3. J Neurol Sci 279(1-2):80-87

Nizri E, Irony-Tur-Sinai M, Lory O, Orr-Urtreger A, Lavi E, Brenner T (2009) Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses. J Immunol 183(10):6681-6688

Irony-Tur-Sinai M, Lichtenstein M, Brenner T, Lorberboum-Galski H (2009) IL2-caspase3 chimeric protein controls lymphocyte reactivity by targeted apoptosis, leading to amelioration of experimental autoimmune encephalomyelitis. Int Immunopharmacol 9(10):1236-1243

Karussis D, Teitelbaum D, Sicsic C, Brenner T (2010) Long-term treatment of multiple sclerosis with glatiramer acetate: natural history of the subtypes of anti-glatiramer acetate antibodies and their correlation with clinical efficacy. J Neuroimmunol 220(1-2):125-130

Reale M, Brenner T, Greig NH, Inestrosa N, Paleacu D (2010) Neuroinflammation, AD and Dementia. Int J Atzheimers Dis 974026

Souroujon MC, Brenner T, Fuchs S (2010) Development of novel therapies for MG: studies in animal models. Autoimmunity 43:446-460

Vaknin-Dembinsky A, Abramsky O, Petrou P, Ben-Hur T, Gotkine M, Brill L, Brenner T, Argov Z, Karussis D (2011) Myasthenia gravis-associated neuromyelitis optica-like disease: an immunological link between the central nervous system and muscle? Arch Neurol 68(12):1557-1561

Nizri E, Brenner T (2011) Modulation of inflammatory pathways by the immune cholinergic system. Amino Acids 45(1):73-85

Blotnick E, Hamra-Amitai Y, Wald C, Brenner T, Anglister L (2012) Changes in acetylcholinesterase in experimental autoimmune myasthenia gravis and in response to treatment with a specific antisense. Eur J Neurosci 36(8):3077-3085

Gur-Wahnon D, Mizrachi T, Maaravi-Pinto FY, Lourbopoulos A, Grigoriadis N, Higazi AA, Brenner T (2013) The plasminogen activator system: involvement in central nervous system inflammation and a potential site for therapeutic intervention. J Neuroinflammation 10:124

Prinz-Hadad H, Mizrachi T, Irony-Tur-Sinai M, Prigozhina TB, Aronin A, Brenner T, Dranitzki-Elhalel M (2013) Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14.TRAIL. J Neuroinflammation 10:36

Zisimopoulou P, Brenner T, Trakas N, Tzartos SJ (2013) Serological diagnostics in myasthenia gravis based on novel assays and recently identified antigens. Autoimmun Rev 12(9):924-930

Gur-Wahnon D, Mizrachi T, Wald-Altman S, Al-Roof Higazi A, Brenner T (2014) Tissue plasminogen activator involvement in experimental autoimmune myasthenia gravis: Aggravation and therapeutic potential. J Autoimmun