Prof. Tamir Ben Hur M.D., Ph.D.

Tamir Ben HurAppointment: Professor of Neurology; Head, Department of Neurology and Division of Medical Neurosciences

Area of expertise: Stem cells, regenerative medicine, neuroimmunology.

Tel: 02-6776941; Email: tamir@hadassah.org.il

 

Selected Research Publications

Shohami E, Gallily R, Mechoulam R, Bass & Ben-Hur T (1997) Cytokine production in the brain following closed head injury: Dexanabinol (HU211) is a novel TNFa inhibitor and an effective neuroprotectant. J Neuroimmunol 72: 169-177

Ben-Hur T, Rogister B, Murray K, Rougon G & Dubois-Dalcq M (1998) Growth and fate of polysialylated neural cell adhesion molecule + precursors of the postnatal brain. J of Neuroscience 18:5777-5788

Keirstead H, Ben-Hur T, Rogister B, O’Leary MT, Dubois-Dalcq M & Blakemore WF (1999) Polysialylated neural cell adhesion molecule – positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation. Jof Neuroscience 19:7529-7536

Reubinoff BE, Itsykson P, Turetsky T, Pera MF, Reinhartz E, Itzik A & Ben-Hur T (2001) Neural progenitors from human embryonic stem cells. Nature Biotechnol 19:1134-1140

Ben-Hur T, Einstein O, Mizrachi-Kol R, Ben-Menachem O, Reinhartz E Karussis D, Abramsky O (2003) Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia 41: 73-80

Bulte JWM, Ben-Hur T, Miller BM, Mizrachi-Kol R, Einstein O, Reinhartz E, Zywicke HA, Douglas T, Frank J (2003) MR microscopy of magnetically labelled neurospheres transplanted into the Lewis EAE rat brain. Mag Res Med 50: 201-205

Einstein O, Karussis D, Grigoriadis N, Mizrachi-Kol R, Reinhartz E, Abramsky O & Ben-Hur T (2003) Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental autoimmune encephalomyelitis. Mol Cell Neurosci 24: 1074-1082

Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, Reubinoff BE (2004) Human embryonic stem cell-derived neural progenitors correct behavioral deficits in a Parkinson rat model. Stem Cells 22:1246-1255

Einstein O, Grigoriadis N, Mizrachi-Kol R, Reinhartz E, Polyzoidou E, Lavon I, Milonas I, Karussis D, Abramsky O, Ben-Hur T (2006) Transplanted neural stem cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis. Experimental Neurology 198(2):275-284

Ben-Hur T, van Heeswijk RB, Einstein O, Aharonowiz M, Xue R, Frost EE, Mori S, Reubinoff BE, Bulte JW (2007) Serial in vivo MR tracking of magnetically labeled neural spheres transplanted in chronic EAE mice. Magn Reson Med 57(1):164-171

Einstein O, Fainstein N, Vaknin I, Mizrachi-Kol R, Reinhartz E, Grigoriadis N, Lavon I, Baniyash M, Lassmann H, Ben-Hur T (2007) Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression. Annals of Neurology 61(3):209-18. This paper received an editorial

Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, Yirmiya R (2008) Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 13(7):717-728

Ben-Shaanan T, Ben-Hur T, Yanai J (2008) Transplantation of neural progenitors enhances production of endogenous cells in the impaired brain. Mol Psychiatry 13(2):222-231

Ben Menachem O, Goshen I, Kreisel T, Ben Menahem Y, Reinhartz E, Ben Hur T, Yirmiya R (2008) Intrahippocampal transplantation of transgenic neural precursor cells over-expressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis. Neuropsychopharmacology 33(9):2251-2262

Fainstein N, Vaknin I, Einstein O, Zisman P, Sasson SZ, Baniyash M, Ben-Hur T (2008) Neural precursor cells inhibit multiple inflammatory signals. Mol Cell Neurosci 39(3):335-341

Aharonowiz M, Einstein O, Fainstein N, Lassmann H, Reubinoff B, Ben-Hur T (2008) Neuroprotective Effect of Transplanted Human Embryonic Stem Cell-derived Neural Precursors in an Animal Model of Multiple Sclerosis. PLoS One 3(9):e3145

Einstein O, Friedman-Levi Y, Grigoriadis N, Ben-Hur T (2009) Transplanted neural precursors enhance host brain-derived myelin regeneration. J Neurosci 29(50):15694-15702

Muja N, Cohen ME, Zhang J, Kim H, Gilad AA, Walczak P, Ben-Hur T, Bulte JW (2011) Neural precursors exhibit distinctly different patterns of cell migration upon transplantation during either the acute or chronic phase of EAE: A serial MR imaging study. Magn Reson Med 65(6):1738-1749

Raz N, Dotan S, Chokron S, Ben-Hur T, Levin N (2012) Demyelination affects temporal aspects of perception: an optic neuritis study. Annals of Neurology 71(4):531-538

Fainstein N, Cohen ME, Ben-Hur T (2012) Time associated decline in neurotrophic properties of neural stem cell grafts render them dependent on brain region-specific environmental support. Neurobiol of Disease 19;49C:41-48

Fainstein N, Einstein O, Cohen ME, Brill L, Lavon I, Ben-Hur T. (2013) Time limited immunomodulatory functions of transplanted neural precursor cells. Glia 61(2):140-149

Ben Menachem-Zidon O, Ben Menahem Y, Ben-Hur T, Yirmiya R (2014) Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer’s disease model. Neuropsychopharmacology 39(2):401-414