Amyloid (5XFAD) tg-mice

[5XFAD (B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/J)] tg-mice present intracellular and extracellular amyloid plaques at 2 months, develop cognitive impairments at 4-5 months and neuronal death at 9 months.



Frydman-Marom A, Levin A, Farfara D, Benromano T, Scherzer-Attali1 R, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M (2011) Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer’s disease animal models. PloS One  6(1):e16564