ALS (SOD1-G93A) tg-mice

B6SJL-TgN[SOD1-G93A]1Gur mice29,  which show Amyotrophic Lateral Sclerosis (ALS) related clinical symptoms starting at  about 14 -15 weeks of age, presenting as weakness progressing into disability to ambulate, with loss of lumbar motor neurons, and death at 18-20 weeks.

Dismod7

References:

Marc G, Leah R, Ofira E, Oded A, Zohar A, Hanna R (2013) Presymptomatic treatment with acetylcholinesterase antisense oligonucleotides prolongs survival in als (G93A-SOD1) mice. BioMed Research International