These mice demonstrate a range of behavioral and neurophysiological abnormalities that resemble symptoms of human anxiety disorders. They are characterized by reduced aggression, increased anxiety like behavior, altered behavioral despair responses and reduced social interaction
Reproduced with permission from John Wiley & Sons, Inc.
Kalueff et al, 2007: Anxious like behavior of WT mice (SERT+/+), heterozygous (SERT +/-) and homozygous (SERT -/-) serotonin transporter knockout in the open field test. Frequency in the arena center (left), duration in arena center (middle) and time in center/ time in periphery are measured. A clear inverse relationship is demonstrated between levels of SERT gene expression and levels of anxiety in all three parameters.
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