BTBR T+tf/J is a genetically homogenous inbred mouse strain that display many autistic like behavioral phenotypes such as reduced reciprocal social interactions, impaired juvenile play, increased repetitive behaviors such as self-grooming and unusual ultrasonic vocalizations in pups and adults.
Reproduced with permission from John Wiley & Sons, Inc.
McFarlane et al, 2008: Social deficits in adult male BTBR mice versus B6 control mice: Interaction between two freely moving same strain mice, as demonstrated by monitoring the social interactions between two freely moving individuals of the same strain. (C) to (E) time spent in total interactions, face sniffing and following time significantly reduced in BTBR mice compared to B6 controls.
Bolivar VJ, Walters SR, Phoenix JL (2007) Assessing autism-like behavior in mice: Variations in social interactions among inbred strains. Behav Brain Res 176(1):21-26
McFarlane HG, Kusek GK, Yang M, Phoenix JL, Bolivar VJ, Crawley JN (2008) Autism-like behavioral phenotypes in BTBR T+TF/J mice. Genes Brain Behav 7(2):152-163