Mice of this strain display, at the age of 30 days but not at more advanced ages, relatively low sociability, reduced reciprocal social interactions, reduced ultrasonic vocalizations in same sex social interaction, reduced place-conditioned social reward and reduced social learning during social distress.
Chen et al, 2009: Juvenile (4 weeks old- left) but not adults (7-8 weeks of age, right) mice display markedly reduced sociability (social investigation) compared to same age C57BL/6J mice.
Chen Q, Panksepp JB, Lahvis GP (2009) Empathy is moderated by genetic background in mice. PLoS One 4:4387
Panksepp JB, Jochman KA, Kim JU, Koy JJ, Wilson ED, Chen Q, Wilson CR, Lahvis GP (2007) Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice. PLoS One 2(4):e351