Pilocarpine model of chronic TLE

This model closely resembles the human disease. Pilocarpine is injected IP in divided doses, after pre-medication with lithium chloride and methyl-scopolamine. About 70% of the animals develop status epilepticus (SE) which is terminated after two hours with diazepam. Those animals will have chronic spontaneous seizures starting 4-8 weeks after SE.



Ekstein D., Dhamne S., Muller P., Loddenkemper T., Pascual-Leone A., Jensen F., Rotenberg A (2011) Cathodal transcranial direct current stimulation suppresses ptz-induced seizures in rats. Epilepsy Currents 11:1 SUPPL. 1.

Glien M, Brandt C, Potschka H, Voigt H, Ebert U, Loscher W (2001) repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy. Epilepsy Res 46(2):111-119