Relapsing EAE

SJL mice are immunized with PLP peptide, to induce an autoimmune response. Lymph node cells are further exposed to the autoantigen in vitro and then injected to another set of SJL mice for passive induction (“transfer”) of EAE.  The clinical course, neuro-inflammation, tissue injury and T cell responses are measured, as in other EAE models.



Einstein O, Fainstein N, Vaknin I, Mizrachi-Kol R, Reihartz E, Grigoriadis N, Lavon I, Baniyash M, Lassmann H, Ben-Hur T (2007) neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression. Ann Neurol 61(3):209-218

Karussis DM, Slavin S, Ben-Nun A, Ovadia H, Vourka-Karussis U, Lehmann D, Mizrachi-Kol R, Abramsky O (1992) Chronic-relapsing experimental autoimmune encephalomyelitis (CR-EAE): treatment and induction of tolerance, with high dose cyclophosphamide followed by syngeneic bone marrow transplantation. J Neuroimmunol 39(3):201-210

Karussis DM, Vourka-Karussis U, Lehmann D, Ovadia H, Mizrachi-Koll R, Ben-Nun A, Abramsky O, Slavin S (1993) Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation. J Clin Invest 92(2):765-772