Relapsing-Progressive EAE

Biozzi AB/H mice are immunized with spinal cord homogenate to induce a chronic relapsing EAE. This model manifests with initial relapsing-remitting course, followed by a relapsing progressive disease, with pathological elements of demyelination, remyelination, axonal loss, gliosis and chronic neuroinflammation. These are reminiscent of progressive multiple sclerosis.