[5XFAD (B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/J)] tg-mice present intracellular and extracellular amyloid plaques at 2 months, develop cognitive impairments at 4-5 months and neuronal death at 9 months.

Memory deficits in T-maze in 5XFAD tg-mice; improvement by experimental therapy	Amyloid plaques IN 5XFAD tg-mice
(From the lab of Hanna Rosenmann)

References

Frydman-Marom A, Levin A, Farfara D, Benromano T, Scherzer-Attali1 R, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M (2011) Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer’s disease animal models. PloS One  6(1):e16564

Binyamin O, Nitzan K, Frid K, Ungar Y, Rosenmann H, Gabizon R. (2019) Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice. Sci Rep  9(1):18437