I.C.V. administration of Aβ peptide in mice induces cognitive impairment and neuronal loss.

Memory deficits in Y-maze and neuronal loss in Aβ ICV injected mice, with improvement by treatment by experimental therapy

References

Nitzan K, Benhamron S, Valitsky M, Kesner EE, Lichtenstein M, Ben-Zvi A, Ella E, Segalstein Y, Saada A, Lorberboum-Galski H, Rosenmann H (2019) Mitochondrial Transfer Ameliorates Cognitive Deficits, Neuronal Loss, and Gliosis in Alzheimer’s Disease Mice. J Alzheimers Dis. 2019;72(2):587-604.

Benhamron S, Nitzan K, Valitsky M,  Karussis M, Kassis I, Rosenmann H (2020) Fluid (CSF) Exchange Therapy with Artificial CSF Enriched with Mesenchymal Stem Cell Secretions Ameliorates Cognitive Deficits and Brain Pathology in Alzheimer’s Disease Mice. J Alzheimers Dis. 2020;76 (1).