Permanent distal middle cerebral artery occlusion (PMCAO) stroke model is used to induce irreversible focal ischemia in rats, inducing a fronto-parietal cortical lesion sparing the subcortical structures. PMCAO can be induced in rats and mice by craniectomy, exposure and electrocoagulation of distal MCA. The model leads to measurable histological damage and to predictable neurological deficits.

References

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Leker RR, Gai N, Mechoulam R, Ovadia H (2003) Drug-induced hypothermia reduces ischemic damage: Effects of the cannabinoid HU-210. Stroke 34(8):2000-2006