Permanent distal middle cerebral artery occlusion (PMCAO) stroke model is used to induce irreversible focal ischemia in rats, inducing a fronto-parietal cortical lesion sparing the subcortical structures. PMCAO can be induced in rats and mice by injection of the photothrombotic dye rose-bengal and irradiation of the brain with a cold light source leading to distal MCAO. The model leads to measurable histological damage and to predictable neurological deficits.

References

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