Cuprizone model of toxic demyelination

C57BL/6 mice are fed with cuprizone for 6-10 weeks to induced widespread demyelination, especially in the splenium of the corpus callosum. Upon discontinuation of cuprizone, a concerted process of remyelination is evident

References

Einstein O, Friedman-Levi Y, Grigoriadis N, Ben-Hur T. (2009) Transplanted neural precursors enhance host brain-derived myelin regeneration J. of Neuroscience. 29(50):15694-702