Biozzi AB/H mice are immunized with spinal cord homogenate to induce a chronic relapsing EAE. This model manifests with initial relapsing-remitting course, followed by a relapsing progressive disease, with pathological elements of demyelination, remyelination, axonal loss, gliosis and chronic neuroinflammation. These are reminiscent of progressive multiple sclerosis.

References

Nishri Y, Hampton D, Ben-Shushan E, Fainstein N, Magnani D, Aharonowiz M, Reubinoff BE, Chandran S, Ben-Hur T (2020). Continuous Immune-Modulatory Effects of Human Olig2+ Precursor Cells Attenuating a Chronic-Active Model of Multiple Sclerosis. Mol Neurobiol. 2020 57(2) :1021-1034