6-hydroxydopamine (6OHDA): Unilateral destruction of dopaminergic neurons, induced by stereotaxic injection of  6OHDA  into the substantia nigra of rats, causes motor deficits after 3 days, with substantia nigra neuronal damage. 6OHDA injected into the medial forebrain bundle induces similar deficits.

References

Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, Reubinoff BE (2004) Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in parkinsonian rats. Stem Cells 22(7):1246-1255