Neurofibrillary tangle (NFT)-tg mice (htauP301S/ K257T) model, generated by us, presents NFT pathology with astrogliosis in the brain, memory deficits and long-term potentiation deficits by 7 months of age. This model serves in addition to Alzheimer’s disease (a secondary tauopathy) also as a model for primary tauopathies (frontotemporal dementia, Pick’s disease).

References

Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E (2008) A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics. Exp Neurol 212(1):71-84

Boimel M, Grigoriadis N, Lourbopoulos A, Rozenstein L, Touloumi O, Rosenmann D, Abramsky O, Rosenmann H (2008) statins reduce neurofibrillary-tangles (NFT) burden in a transgenic (TG) mouse model for tauopathy and for alzheimer’s-disease (AD).  J Neural Transm.  pp 1479-1479

Exposure to 3-Nitropropionic Acid Mitochondrial Toxin Induces Tau Pathology in Tangle-Mouse Model and in Wild Type-Mice (2020)    Lahiani-Cohen I, Touloumi O, Lagoudaki R, Grigoriadis N, Rosenmann H. Front Cell Dev Biol 14;7:321