The following outcome measures are available at Hadassah Brainlabs:
Behavioral Analysis
Motor domain
Motor Scores
Grip test; Catalepsy test; Open field; Cylinder test; Rotarod
Clinical Scores
EAE; ALS; Prion; NSS
Parkinson’s Disease Scores
Non-Pharmacological: Stepping, Placing, Wire grasping test, Pole test
Pharmacological: Rotational asymmetry
Cognitive, learning and memory domain
Novel object recognition; Morris water maze: Attentional set shifting; Radial arm water maze; Cued and context fear conditioning; T-maze; Y-maze
Psychosis-like domain
MK801 – induced hyperlocomotion; MK-801-induced pre-pulse inhibition
Depressive-like domain
Forced swim test; Novelty suppressed feeding; Saccharin preference; Tail suspension
Anxiety-like domain
Elevated plus maze; Open field; Light-dark box; Stress induced hyperthermia; Startle response; Peripheral stress-related biomarkers (corticosterone, ACTH)
Social domain
Three chambers sociability and social novelty test; Social interaction in pairs; Resident intruder test
Intellicage
This programmable cage uses sophisticated software;
Neuropathology
Cells in the CNS
Neurons, Astrocytes, Microglia, Oligodendrocytes; Blood vessels; Transplanted cells; Neurogenesis
Neuroinflammation
T-cells, B-cells, Microglia/Macrophages, Perivascular/ Meningeal Infiltrates
Neurodegeneration
Neurofibrillary tangles, Amyloid plaques; De/Myelination; Axonal damage; Prions; Apoptosis
Biochemical Analysis
Proteins (Soluble, resistant, phosphorylated, glycosylated)
Immunological Assays
T-cell proliferation, Ab titers